5 Easy Facts About mif Described

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MIF has various biological roles, With all the most significant becoming inflammation and immunity. MIF counter-regulates the actions of glucocorticoids, which happen to be all-natural steroid hormones produced by the adrenal glands in mif the course of cellular strain that possess anti-inflammatory results [5]. MIF might stimulate the expression of other cytokines involved with inflammation. Inflammation is necessary for the survival of organisms, but when it really is improperly controlled, it may well lead to tumorigenesis [6].

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Macrophage migration inhibitory element (MIF) is among the very first described cytokines, recognized for a soluble immune cell-derived factor around fifty many years back in 1966. Similar to cytokines including tumor necrosis aspect (TNF), MIF's choice of functions has exceeded what's implied via the historic name (five, six). The MIF gene was cloned in 1989, and subsequent studies have demonstrated a wide array of roles for MIF. MIF is A really pleiotropic inflammatory cytokine that is expressed by a range of cells, which is a critical upstream mediator of innate immunity.

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